abstract：BACKGROUND:There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response. METHOD:A literature search was conducted to identify clinical studies of antipsychotics in TRS using PubMed, EMBASE and PsycINFO (last search 31 July 2011). Psychopharmacological stud...

journal_title：Schizophrenia research

authors： Suzuki T,Remington G,Mulsant BH,Rajji TK,Uchida H,Graff-Guerrero A,Mamo DC

更新日期：2011-12-01 00:00:00

abstract：:A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schiz...

journal_title：Schizophrenia research

authors： Høye A,Jacobsen BK,Hansen V

更新日期：2011-11-01 00:00:00

abstract：:An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spon...

journal_title：Schizophrenia research

authors： Mittal VA,Dean DJ,Pelletier A,Caligiuri M

更新日期：2011-11-01 00:00:00

abstract：:We conducted data-mining analyses of genome wide association (GWA) studies of the CATIE and MGS-GAIN datasets, and found 13 markers in the two physically linked genes, PTPN21 and EML5, showing nominally significant association with schizophrenia. Linkage disequilibrium (LD) analysis indicated that all 7 markers from P...

journal_title：Schizophrenia research

authors： Chen J,Lee G,Fanous AH,Zhao Z,Jia P,O'Neill A,Walsh D,Kendler KS,Chen X,International Schizophrenia Consortium.

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The Positive and Negative Syndrome Scale (PANSS) total score is widely used to assess antipsychotic efficacy, however schizophrenia is a multi-dimensional disorder. We conducted a 5-factor analysis for evaluating the efficacy of iloperidone vs. placebo across these different domains in the treatment of schiz...

journal_title：Schizophrenia research

authors： Citrome L,Meng X,Hochfeld M

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...

journal_title：Schizophrenia research

authors： Stroup TS,Appelbaum PS,Gu H,Hays S,Swartz MS,Keefe RS,Kim SY,Manschreck TC,Boshes RA,McEvoy JP,Lieberman JA

更新日期：2011-08-01 00:00:00

abstract：:Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...

journal_title：Schizophrenia research

authors： Simeonova DI,Attalla A,Trotman H,Esterberg M,Walker EF

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been e...

journal_title：Schizophrenia research

authors： Abdolmaleky HM,Yaqubi S,Papageorgis P,Lambert AW,Ozturk S,Sivaraman V,Thiagalingam S

更新日期：2011-07-01 00:00:00

abstract：:In this study, we examined the preliminary concurrent validity of a brief version of the Prodromal Questionnaire (PQ-B), a self-report screening measure for psychosis risk syndromes. Adolescents and young adults (N=141) who presented consecutively for clinical assessment to one of two early psychosis research clinics ...

journal_title：Schizophrenia research

authors： Loewy RL,Pearson R,Vinogradov S,Bearden CE,Cannon TD

更新日期：2011-06-01 00:00:00

abstract：:Recent preclinical and clinical evidence suggests that the stearoyl-CoA desaturase-1 (Scd1) enzyme plays a key role in the regulation of triglyceride (TG) biosynthesis and insulin sensitivity, and in vitro studies have found that antipsychotic medications up-regulate Scd1 mRNA expression. To investigate these effects ...

journal_title：Schizophrenia research

authors： McNamara RK,Jandacek R,Rider T,Tso P,Cole-Strauss A,Lipton JW

更新日期：2011-06-01 00:00:00

abstract：:Disrupted-in-Schizophrenia 1 (DISC1), a strong candidate gene for schizophrenia and other mental disorders, regulates neurodevelopmental processes including neurogenesis, neuronal migration, neurite outgrowth and spine development. Glycogen synthase kinase-3 (GSK3) directly interacts with DISC1 and also plays a role i...

journal_title：Schizophrenia research

authors： Lee FH,Kaidanovich-Beilin O,Roder JC,Woodgett JR,Wong AH

更新日期：2011-06-01 00:00:00

abstract：:A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subject...

journal_title：Schizophrenia research

authors： Maïza O,Mazoyer B,Hervé PY,Razafimandimby A,Dollfus S,Tzourio-Mazoyer N

更新日期：2011-05-01 00:00:00

abstract：:The current study examined whether patterns of emotional response are differentially associated with symptom presentation and functional outcome in individuals with schizophrenia. Participants included 49 outpatients with schizophrenia and 50 demographically matched controls. All participants rated their emotional res...

journal_title：Schizophrenia research

authors： Strauss GP,Herbener ES

更新日期：2011-05-01 00:00:00

abstract：:Recent molecular genetic studies have demonstrated X-chromosome abnormalities in the transmission of psychosis, a finding that may contribute to understanding sex differences in the disorder. Using our family high risk paradigm, we tested the hypothesis that there are sex-specific patterns of transmission of psychosis...

journal_title：Schizophrenia research

authors： Goldstein JM,Cherkerzian S,Seidman LJ,Petryshen TL,Fitzmaurice G,Tsuang MT,Buka SL

更新日期：2011-05-01 00:00:00

abstract：:Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among inpatients. In this study, we examine...

journal_title：Schizophrenia research

authors： Combs DR,Chapman D,Waguspack J,Basso MR,Penn DL

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Impaired insight into illness is common during early psychosis and has been associated with treatment delays and poorer long-term outcomes. The relationship between patients' insight into illness and their caregivers' knowledge about psychosis is putatively associated with treatment outcome but there is limi...

journal_title：Schizophrenia research

authors： Brent BK,Giuliano AJ,Zimmet SV,Keshavan MS,Seidman LJ

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...

journal_title：Schizophrenia research

authors： Harvey PO,Lee J,Horan WP,Ochsner K,Green MF

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Studies in first episode psychosis samples about status of cardiovascular risk factors have shown discordant results. We aimed to determine the 10-year risk of developing coronary heart disease in a sample of first episode psychosis patients referred to an early intervention clinic and compared the same with ...

journal_title：Schizophrenia research

authors： Phutane VH,Tek C,Chwastiak L,Ratliff JC,Ozyuksel B,Woods SW,Srihari VH

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders. METHODS:766 patients, aged 16 to 65 years, were assessed with the Composite International Diagnostic Interview (CIDI) for substance abu...

journal_title：Schizophrenia research

authors： De Hert M,Wampers M,Jendricko T,Franic T,Vidovic D,De Vriendt N,Sweers K,Peuskens J,van Winkel R

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:The diagnosis of psychotic disorder is associated with a risk of violence. Psychotic-like experiences (PLEs) in the general population may share an etiological background with psychotic disorders. The present study has evaluated the association between PLEs and violent behavior in adolescents. METHODS:PLEs a...

journal_title：Schizophrenia research

authors： Kinoshita Y,Shimodera S,Nishida A,Kinoshita K,Watanabe N,Oshima N,Akechi T,Sasaki T,Inoue S,Furukawa TA,Okazaki Y

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:In randomized controlled trials of antipsychotics, various cutoffs have been used to define response on continuous outcome measures. AIMS:To find a summary effect measure that remains constant across different definitions of response. METHOD:We conducted secondary analyses of individual patient data from 1...

journal_title：Schizophrenia research

authors： Furukawa TA,Akechi T,Wagenpfeil S,Leucht S

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To examine childhood ADHD symptoms in regard to their association with a number of illness-related variables including risk factors, early neurodevelopment, premorbid functioning and clinical characteristics in patients with schizophrenia-spectrum psychoses. METHODS:One-hundred and twenty-two first-episode p...

journal_title：Schizophrenia research

authors： Peralta V,de Jalón EG,Campos MS,Zandio M,Sanchez-Torres A,Cuesta MJ

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:The relationship of religion and schizophrenia is widely acknowledged, but often minimized by practitioners and under investigated by researchers. In striving to help fill this gap, this paper focuses on examining four aims: 1) how research has investigated the association between religiosity and schizophreni...

journal_title：Schizophrenia research

authors： Gearing RE,Alonzo D,Smolak A,McHugh K,Harmon S,Baldwin S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Symptomatic remission and its associated factors have been evaluated in several studies of younger schizophrenic patients. Although the number of older individuals with schizophrenia is rapidly growing, evaluations of remission in elderly patients are scarce and limited to samples of convenience, questioning...

journal_title：Schizophrenia research

authors： Meesters PD,Comijs HC,de Haan L,Smit JH,Eikelenboom P,Beekman AT,Stek ML

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The extent of heterogeneity in the long-term course of schizophrenia is unclear. AIMS:To examine the course of schizophrenia in a population-based cohort. METHODS:This study included all Israeli individuals born in 1970-1988, of North African or European origin (N=2290), entered in the National Psychiatric...

journal_title：Schizophrenia research

authors： Levine SZ,Lurie I,Kohn R,Levav I

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Project produced a battery of tests, the MATRICS Consensus Cognitive Battery (MCCB), designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. In validation studies, the MCCB demonstr...

journal_title：Schizophrenia research

authors： Keefe RS,Fox KH,Harvey PD,Cucchiaro J,Siu C,Loebel A

更新日期：2011-02-01 00:00:00

abstract：:Social anhedonia is an important feature of schizophrenia and it is a promising indicator of schizotypy. Although social anhedonia is defined as an affective construct (less pleasure derived from social encounters), little is known about the emotional responsivity and expressivity of individuals with high levels of so...

journal_title：Schizophrenia research

authors： Leung WW,Couture SM,Blanchard JJ,Lin S,Llerena K

更新日期：2010-12-01 00:00:00

abstract：:Studies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to n...

journal_title：Schizophrenia research

authors： Barbour T,Murphy E,Pruitt P,Eickhoff SB,Keshavan MS,Rajan U,Zajac-Benitez C,Diwadkar VA

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:EEG power in the delta, theta and beta1 bands has been shown to be positively correlated with negative symptoms in first episode psychotic patients. The present study investigates this correlation in an "at risk mental state for psychosis" (ARMS) with the aim to improve prediction of transition to psychosi...

journal_title：Schizophrenia research

authors： Zimmermann R,Gschwandtner U,Wilhelm FH,Pflueger MO,Riecher-Rössler A,Fuhr P

更新日期：2010-11-01 00:00:00

abstract：:Attention deficits are considered to be fundamental in patients with schizophrenia. During attention tasks, patients with schizophrenia have been shown to display increased brain activity in some neuroimaging studies but reduced brain activity in others. These conflicting findings may be due to some study designs prim...

journal_title：Schizophrenia research

authors： Carter JD,Bizzell J,Kim C,Bellion C,Carpenter KL,Dichter G,Belger A

更新日期：2010-09-01 00:00:00

abstract：:High nailfold plexus visibility (NPV) is a trait identifying a putative endophenotype for schizophrenia. We describe a new method of NPV assessment using computer storage of digital photomicrographs. We performed a reliability study of this method using 40 subjects. The intraclass correlation between two blinded rater...

journal_title：Schizophrenia research

authors： Miranowski SK,Vuchetich JP

更新日期：2010-09-01 00:00:00

abstract：:Recent trials support the hypothesis of the role of inflammation in the pathogenesis of schizophrenia. The overall therapeutic benefit of anti-inflammatory medication, in particular cyclo-oxygenase-2 (COX-2) inhibitors in schizophrenia, is still controversial. There are suggestions that therapy with COX-2 inhibitors m...

journal_title：Schizophrenia research

authors： Müller N,Krause D,Dehning S,Musil R,Schennach-Wolff R,Obermeier M,Möller HJ,Klauss V,Schwarz MJ,Riedel M

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Vesicular glutamate transporters (VGLUT1-3) package glutamate into vesicles in the presynaptic terminal and regulate the release of glutamate. In mesencephalic dopamine neuron culture, the majority of isolated dopamine neurons express VGLUT2, but not VGLUT1 or 3, have been demonstrated. As related to the dys...

journal_title：Schizophrenia research

authors： Shen YC,Liao DL,Lu CL,Chen JY,Liou YJ,Chen TT,Chen CH

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:D-serine is an allosteric modulator of the brain N-methyl-d-aspartate (NMDA) receptor and a potential novel treatment of schizophrenia. Double-blind studies have been performed at 30 mg/kg/day (approximately 2 g/day) with encouraging results, but no formal dose escalation studies have been performed. We desc...

journal_title：Schizophrenia research

authors： Kantrowitz JT,Malhotra AK,Cornblatt B,Silipo G,Balla A,Suckow RF,D'Souza C,Saksa J,Woods SW,Javitt DC

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present...

journal_title：Schizophrenia research

authors： Cullen AE,Dickson H,West SA,Morris RG,Mould GL,Hodgins S,Murray RM,Laurens KR

更新日期：2010-08-01 00:00:00

abstract：:While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...

journal_title：Schizophrenia research

authors： Yang LH,Wonpat-Borja AJ,Opler MG,Corcoran CM

更新日期：2010-07-01 00:00:00

abstract：:The results of research on the relation of family history (FH) of psychosis with clinical presentation in schizophrenia have been mixed. To date, there have been no comprehensive reviews that have examined this body of research. The current review quantitatively evaluates research on the relation of FH with two aspect...

journal_title：Schizophrenia research

authors： Esterberg ML,Trotman HD,Holtzman C,Compton MT,Walker EF

更新日期：2010-07-01 00:00:00

abstract：:Association with schizophrenia of the Abelson Helper Integration Site 1 (AHI1) gene on chromosome 6q23 and the adjacent primate-specific gene, C6orf217, was demonstrated in an inbred, Arab Israeli family sample and replicated in an Icelandic case control sample. Further support was provided by a second replication in ...

journal_title：Schizophrenia research

authors： Slonimsky A,Levy I,Kohn Y,Rigbi A,Ben-Asher E,Lancet D,Agam G,Lerer B

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the g...

journal_title：Schizophrenia research

authors： Breetvelt EJ,Boks MP,Numans ME,Selten JP,Sommer IE,Grobbee DE,Kahn RS,Geerlings MI

更新日期：2010-07-01 00:00:00

abstract：:Neurodevelopmental pathogenesis of schizophrenia might be mediated by abnormalities in Insulin-like Growth Factor-1 (IGF-1). Developmental disturbances like obstetric complications, by themselves, as well as through the resultant hypercortisolemia due to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, can lea...

journal_title：Schizophrenia research

authors： Venkatasubramanian G,Chittiprol S,Neelakantachar N,Shetty T,Gangadhar BN

更新日期：2010-06-01 00:00:00